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The "junk DNA"
may be useful in developing future cancer treatments, according to a new report
in the journal Nature Immunology. The discovery was led by Wilmot Cancer
Institute investigators and University of Rochester biologists Vera Gorbunova,
Ph.D., and Andrei Seluanov, Ph.D..
The DNA elements under
research are known as retrotransposons (逆转录转座子). The bad side of them is that if left to run amok, they can
give rise to tumors (肿瘤). Researchers, however,
discovered that if they are kept in the correct balance and controlled
properly, retrotransposons can cause the immune system to destroy cancer.
Much of the Gorbunova
and Seluanov lab's work involves the blind mole rat (鼹鼠), which lives underground and seems unaffected by cancer. In the
latest scientific paper, researchers found that the anti-cancer approaches behind
retrotransposons are present in human cells, and planned to use the information
to find new ways to stop cancer cell growth.
They focus on rats
because they are genetically similar to humans and have a diverse range of
lifespans (寿命). Gorbunova and Seluanov previously
discovered that blind mole rats prevent cancer by activating "concerted cell
death," but the approaches at play were a mystery. Now, the researchers
believe retrotransposons may be one key piece to the puzzle. Why? Because they
discovered that blind mole rats have evolved to retrotransposons to their
advantage to kill cancer cells.
At first the
researchers believed the approaches behind retrotransposons were unique to
blind mole rats. However, they found the same approaches at work in human
tissue cells. The researchers still need to figure out exactly how blind mole
rats have achieved the balance between activating and controlling
retrotransposons. For now, though, they will focus on the power of selfish
genetic elements to be, well, not so selfish.
(1)
What is one of reasons for rats to be chosen as study topic?
A . They are unaffected by cancer.
B . They have overlong lifespans.
C . Their genes are alike to humans.
D . Their retrotransposons are unique.
(2)
What does the underlined "amok" in paragraph 2 mean?
A . Unbelievably.
B . Unreasonably.
C . Insensitively.
D . Independently.
(3)
What can we know about the lab's research?
A . It developed possible treatments for cancer.
B . It transplanted retrotransposons into human.
C . It succeeded in balancing retrotransposons.
D . It removed junk genes from rats effectively.
(4)
Which is the most suitable title for the text?
A . Blind Mole Rats Fight against Cancer
B . "Junk DNA" is a Double-Edged Sword
C . Blind Mole Rats: Close Friends of Humanity
D . Selfish Genetic Elements Have Great Power
答案: C
B
A
B